How does bromadiolone work on dogs? - briefly
Bromadiolone is an anticoagulant rodenticide that works by inhibiting vitamin K epoxide reductase in dogs, preventing the recycling of vitamin K and leading to a deficiency in clotting factors, ultimately causing fatal internal bleeding. The compound is highly toxic to dogs due to its potency and delayed onset of symptoms, making prompt veterinary intervention crucial.
How does bromadiolone work on dogs? - in detail
Bromadiolone is a potent anticoagulant rodenticide that works by interfering with the blood clotting process in animals, including dogs. When a dog ingests bromadiolone, it disrupts the normal functioning of vitamin K, an essential nutrient for blood coagulation.
Vitamin K is crucial for the activation of certain proteins involved in blood clotting, such as factors II, VII, IX, and X. These proteins are initially produced in an inactive form, and vitamin K plays a vital role in converting them into their active forms. Bromadiolone acts as an antagonist to vitamin K, preventing its action on these clotting factors. As a result, the body is unable to produce functional clotting proteins, leading to uncontrolled bleeding both internally and externally.
The symptoms of bromadiolone poisoning in dogs typically appear within 24-48 hours after ingestion. These may include lethargy, pale gums, weakness, labored breathing, and signs of internal or external hemorrhage such as blood in the urine, feces, or from any orifices. In severe cases, dogs may exhibit neurological symptoms like seizures or paralysis due to bleeding into the brain.
The treatment for bromadiolone poisoning involves supportive care and administration of vitamin K1 (phytonadione), which can help reverse the anticoagulant effects. However, the prognosis depends on the severity of the symptoms and the time elapsed since ingestion. Early detection and prompt veterinary intervention are crucial for successful treatment outcomes.
In summary, bromadiolone works by inhibiting vitamin K-dependent blood clotting in dogs, leading to uncontrolled bleeding and potentially life-threatening complications. Pet owners should be aware of the risks associated with this substance and take necessary precautions to prevent accidental ingestion by their pets.