How does Simparica work on ticks in dogs? - briefly
Simparica works by targeting and killing ticks that attach to dogs. The active ingredient, sarolaner, is absorbed into the dog's bloodstream, making it lethal for ticks when they feed on the treated animal.
How does Simparica work on ticks in dogs? - in detail
Simparica (sarolaner) is a highly effective medication designed to protect dogs from tick infestations. The active ingredient, sarolaner, is a member of the isoxazoline class of compounds and acts as an insecticide and acaricide. Its primary mode of action involves targeting the nervous system of ticks, leading to their paralysis and eventual death.
Upon administration, Simparica is rapidly absorbed into the dog's bloodstream. Ticks feed on the dog's blood, ingesting the sarolaner present in the blood. Once inside the tick, sarolaner binds to specific receptors in the insect's central nervous system, particularly those associated with gamma-aminobutyric acid (GABA) and glutamate neurotransmitters. This binding action disrupts the normal functioning of these neurotransmitters, causing uncontrolled neuronal activity and subsequent paralysis of the tick.
The disruption in neuronal signaling prevents ticks from completing their life cycle, which includes feeding, molting, and reproduction. As a result, ticks die within 24-48 hours after coming into contact with the treated dog. This rapid onset of action ensures that Simparica provides comprehensive protection against tick infestations throughout its one-month duration of effectiveness.
Moreover, Simparica exhibits a unique mechanism that enhances its effectiveness. Ticks that feed on a treated dog may transfer sarolaner to other ticks during the feeding process. This secondary exposure further contributes to the control and elimination of tick populations, providing an additional layer of protection for the dog and the environment.
In summary, Simparica's efficacy against ticks in dogs is attributed to its ability to target and disrupt the nervous system functions of ticks, leading to their paralysis and death. The medication's rapid absorption, specific receptor binding, and secondary transfer properties collectively contribute to its robust tick control capabilities.