What breeds of dogs cannot have ivermectin? - briefly
Some breeds of dogs are particularly sensitive to ivermectin due to a genetic mutation that affects their blood-brain barrier. These include Collies, Australian Shepherds, Old English Sheepdogs, and Shetland Sheepdogs. It is crucial to consult with a veterinarian before administering ivermectin to any dog, especially those of these breeds.
What breeds of dogs cannot have ivermectin? - in detail
Ivermectin is a potent antiparasitic drug widely used in veterinary medicine, particularly for treating mange and other parasitic infestations in dogs. However, certain breeds of dogs are highly sensitive to ivermectin due to a mutation in the MDR1 gene, which regulates the blood-brain barrier. This genetic predisposition can lead to severe neurological toxicity if ivermectin is administered at standard doses.
The breeds most commonly affected by this sensitivity include:
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Collies: Both smooth and rough collies are particularly susceptible to ivermectin toxicity. The MDR1 gene mutation is prevalent in these breeds, making them highly sensitive to many drugs besides ivermectin.
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Australian Shepherds: Like collies, Australian shepherds often carry the MDR1 gene mutation, which can result in severe adverse reactions to ivermectin.
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Shelties (Shetland Sheepdogs): Shelties are another breed that frequently carries the MDR1 gene mutation, putting them at risk for neurological side effects when exposed to ivermectin.
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Old English Sheepdogs: This breed is also known to have a higher incidence of the MDR1 gene mutation, making them sensitive to ivermectin.
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German Shepherds: While not as commonly affected as the other breeds listed, some German shepherds may carry the MDR1 gene mutation and should be monitored closely if given ivermectin.
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English Shepherds: Similar to their German counterparts, English shepherds can also carry the MDR1 gene mutation, albeit less frequently.
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Skylarks (Island Dog): This lesser-known breed from the Azores is another example of a dog that may carry the MDR1 gene mutation and be sensitive to ivermectin.
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Silken Windhounds: Although not as well-documented, some silken windhounds may also carry the MDR1 gene mutation, making them potentially sensitive to ivermectin.
It is crucial for veterinarians and dog owners to be aware of these sensitivities. If a dog from one of these breeds requires treatment with ivermectin, it is essential to perform genetic testing or consult with a veterinary specialist to determine the safest course of action. Administering ivermectin to sensitive dogs can result in serious neurological symptoms such as ataxia, tremors, seizures, and even death if not promptly addressed.
In summary, while ivermectin is an effective treatment for many parasitic conditions in dogs, it should be used with extreme caution in breeds known to carry the MDR1 gene mutation. Proper diagnosis and genetic testing can help ensure the safe administration of this drug and prevent potentially fatal complications.