What is used to poison dogs with isoniazid? - briefly
Isoniazid is commonly used in dog poisoning due to its toxic effects on canine liver function. This drug, primarily used for treating tuberculosis, can cause severe hepatotoxicity when ingested by dogs, leading to acute liver failure and death if not treated promptly.
What is used to poison dogs with isoniazid? - in detail
Isoniazid, primarily known as an antibiotic used to treat tuberculosis in humans and animals, can be dangerous for dogs if not administered correctly. The substance most commonly associated with isoniazid poisoning in dogs is pyrazinamide, another antitubercular drug. When these medications are combined or given in excess, they can lead to severe toxicity in canines.
Isoniazid itself is metabolized by the liver into a compound called hydrazine, which can be harmful if not properly detoxified. In dogs, the primary concern with isoniazid poisoning is the development of hepatotoxicity, or liver damage. Symptoms of isoniazid toxicity in dogs may include lethargy, loss of appetite, vomiting, abdominal pain, and in severe cases, seizures and coma.
The treatment for isoniazid poisoning in dogs typically involves supportive care, such as intravenous fluids to maintain hydration and electrolyte balance, and potentially the administration of specific antidotes like pyridoxine (vitamin B6), which can help counteract the toxic effects of hydrazine. In some cases, liver protective medications may also be prescribed.
To prevent isoniazid poisoning in dogs, it is crucial to store and administer these medications carefully, following veterinary instructions precisely. If a dog accidentally ingests isoniazid or shows symptoms of poisoning, prompt veterinary attention is essential for a successful outcome.