Why Diclofenac is dangerous for dogs? - briefly
Diclofenac is highly toxic to dogs because it inhibits the production of prostaglandins, which are essential for maintaining proper kidney function. The drug can quickly lead to acute kidney failure and even death in dogs if not treated immediately.
Why Diclofenac is dangerous for dogs? - in detail
Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), is commonly used in human medicine for its analgesic and anti-inflammatory properties. However, it poses significant risks when administered to dogs. The danger of diclofenac for canines lies in several critical factors:
Firstly, dogs metabolize drugs differently than humans. Specifically, they lack certain enzymes that are crucial for the safe breakdown and excretion of NSAIDs like diclofenac. This deficiency leads to a prolonged half-life of the drug within their system, increasing the risk of toxic accumulation over time.
Secondly, diclofenac can cause severe gastrointestinal ulceration in dogs. While humans have mechanisms to counteract the irritating effects of NSAIDs on the stomach lining, dogs do not possess these protective measures. The prolonged exposure to diclofenac can result in significant damage to the intestinal tract, leading to bleeding and perforation—life-threatening conditions that require immediate veterinary intervention.
Moreover, diclofenac affects renal function in dogs. It can reduce blood flow to the kidneys, a critical organ for filtering waste products from the body. Prolonged use or overdose of diclofenac may lead to acute kidney failure, which is often irreversible and fatal if not treated promptly.
Additionally, diclofenac can interfere with blood clotting mechanisms in dogs. By inhibiting the production of prostaglandins, which play a role in platelet aggregation, diclofenac can cause prolonged bleeding times. This effect is particularly dangerous if the dog requires surgery or experiences internal bleeding due to other causes.
Lastly, diclofenac's potent anti-inflammatory properties can mask symptoms of underlying diseases. For instance, a dog with an infection or injury might not show typical signs of distress because diclofenac suppresses inflammation and pain. This can delay necessary treatment and worsen the condition, leading to more severe complications.
In conclusion, diclofenac's dangerous effects on dogs stem from their unique physiology and metabolic processes. The risk of gastrointestinal ulceration, renal failure, prolonged bleeding times, and masking of symptoms underscores the importance of avoiding this medication for canine use. Veterinarians recommend using species-specific NSAIDs that are formulated with the safety profiles of dogs in mind to ensure their well-being and prevent potential harm.