Why is Tubazid deadly for dogs? - briefly
Tubazid contains isoniazid, which dogs cannot metabolize effectively due to genetic differences. This leads to toxic accumulation in their bodies, causing severe and potentially fatal neurological issues.
Why is Tubazid deadly for dogs? - in detail
The active ingredient in Tubazid, known as azithromycin, can be highly toxic to dogs due to several reasons. Firstly, dogs metabolize azithromycin differently than humans. In dogs, this process is significantly slower, leading to higher and prolonged concentrations of the drug in their system. This increased exposure can result in severe adverse effects, including gastrointestinal upset, liver toxicity, and even death in some cases.
Secondly, azithromycin has a narrow therapeutic index, meaning there is a small margin between an effective dose and a toxic one. For dogs, this window is even narrower, making it easier for them to reach toxic levels. The drug is known to accumulate in the liver, which can lead to hepatotoxicity—a condition where the liver cells are damaged or destroyed. Symptoms of liver damage may include lethargy, loss of appetite, vomiting, and jaundice.
Additionally, azithromycin is excreted primarily through bile in dogs, which further contributes to its hepatotoxic potential. This route of excretion can lead to a buildup of the drug within liver cells, causing more significant damage over time. The slow metabolism and excretion rates in dogs make them particularly vulnerable to azithromycin toxicity.
It is crucial for pet owners to be aware of these risks and to consult with a veterinarian before administering any medication intended for human use to their pets. Only medications specifically prescribed by a veterinarian should be given to dogs, as they are formulated with the unique physiology and metabolic processes of canines in mind.