What is the lethal gene in dogs?

What is the lethal gene in dogs? - briefly

The lethal gene in dogs refers to the MDR1 (Multidrug Resistance 1) mutation, which is found primarily in herding breeds such as Collies and Australian Shepherds. This gene causes heightened sensitivity to certain drugs like ivermectin, leading to potential toxicity if not managed properly.

What is the lethal gene in dogs? - in detail

The term "lethal gene" in canines typically refers to genetic mutations that are fatal or significantly debilitating, often resulting in early death or severe health issues. These genes are inherited from one or both parents and can manifest in various ways depending on the specific mutation. Some of the most well-known lethal genes in dogs include:

1. Centronuclear Myopathy (CNM): This is a progressive muscle weakness disorder found in several breeds, including Labrador Retrievers and Rottweilers. The gene responsible for CNM is autosomal recessive, meaning both parents must carry the mutation for the offspring to be affected.

2. Degenerative Myelopathy (DM): Common in German Shepherds and other breeds, DM is a progressive neurodegenerative disease that affects the spinal cord. The gene associated with DM is also autosomal recessive.

3. Exercise-Induced Collapse (EIC): Primarily affecting Labrador Retrievers, EIC causes dogs to experience muscle weakness and collapse after strenuous exercise. This condition is caused by an autosomal dominant gene.

4. Mucopolysaccharidosis Type VII (MPS VII): This lysosomal storage disorder affects various breeds, including the German Shorthaired Pointer and Wirehaired Dachshund. The gene responsible for MPS VII is autosomal recessive.

5. Progressive Retinal Atrophy (PRA): A group of genetic disorders that affect the retina, leading to blindness. PRA is found in many breeds and can be caused by various autosomal recessive genes.

6. Hereditary Cataracts: This condition causes clouding of the lens of the eye, often leading to vision loss. The gene for hereditary cataracts is autosomal dominant in some breeds like the Boston Terrier and French Bulldog.

The impact of these lethal genes can be profound, not only on the affected dogs but also on their owners and breeders. Responsible breeding practices, including genetic testing and selective breeding, are crucial for reducing the prevalence of these conditions in future generations. Owners should be aware of the specific health issues associated with their dog's breed and consult with veterinarians regarding preventative measures and early detection strategies.